Ontology highlight
ABSTRACT:
SUBMITTER: Dimant H
PROVIDER: S-EPMC3963877 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Dimant Hemi H Zhu Liya L Kibuuka Laura N LN Fan Zhanyun Z Hyman Bradley T BT McLean Pamela J PJ
PloS one 20140324 3
Parkinson's disease is a neurodegenerative disorder characterized by Lewy bodies, a pathological hallmark comprised mostly of aggregated alpha synuclein. Accumulating evidence demonstrates the association of smaller oligomeric aggregates to disease etiology and many therapeutic approaches are aimed at inhibiting and reducing the aggregation process. Molecular chaperones and co-chaperones play a key role in protein homeostasis and have potential as therapeutics to inhibit alpha synuclein associat ...[more]