Ontology highlight
ABSTRACT:
SUBMITTER: Albert S
PROVIDER: S-EPMC6969544 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Albert Sahradha S Wietrzynski Wojciech W Lee Chia-Wei CW Schaffer Miroslava M Beck Florian F Schuller Jan M JM Salomé Patrice A PA Plitzko Jürgen M JM Baumeister Wolfgang W Engel Benjamin D BD
Proceedings of the National Academy of Sciences of the United States of America 20191227 2
To promote the biochemical reactions of life, cells can compartmentalize molecular interaction partners together within separated non-membrane-bound regions. It is unknown whether this strategy is used to facilitate protein degradation at specific locations within the cell. Leveraging in situ cryo-electron tomography to image the native molecular landscape of the unicellular alga <i>Chlamydomonas reinhardtii</i>, we discovered that the cytosolic protein degradation machinery is concentrated with ...[more]