Ontology highlight
ABSTRACT:
SUBMITTER: Pishesha N
PROVIDER: S-EPMC3964037 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Pishesha Novalia N Thiru Prathapan P Shi Jiahai J Eng Jennifer C JC Sankaran Vijay G VG Lodish Harvey F HF
Proceedings of the National Academy of Sciences of the United States of America 20140303 11
Mouse models have been used extensively for decades and have been instrumental in improving our understanding of mammalian erythropoiesis. Nonetheless, there are several examples of variation between human and mouse erythropoiesis. We performed a comparative global gene expression study using data from morphologically identical stage-matched sorted populations of human and mouse erythroid precursors from early to late erythroblasts. Induction and repression of major transcriptional regulators of ...[more]