Ontology highlight
ABSTRACT:
SUBMITTER: Shay T
PROVIDER: S-EPMC3581886 | biostudies-other | 2013 Feb
REPOSITORIES: biostudies-other
Shay Tal T Jojic Vladimir V Zuk Or O Rothamel Katherine K Puyraimond-Zemmour David D Feng Ting T Wakamatsu Ei E Benoist Christophe C Koller Daphne D Regev Aviv A
Proceedings of the National Academy of Sciences of the United States of America 20130204 8
Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal than comprehensive evidence. To this end, we compare two large compendia of transcriptional profiles of human and mouse immune cell types. Global transcription profiles are conserved between corresponding cell lineages. The expression patterns of most orthologous genes are co ...[more]