Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Full-range magnetic manipulation of droplets via surface energy traps enables complex bioassays.

ABSTRACT: Manipulating droplets on an open surface promises an easier, more flexible, and more scalable platform of liquid control, than does microchannel-based fluidics. In this report, a surface-energy-trap-enabled magnetic droplet handling platform is introduced that is capable of comprehensive droplet manipulations, including droplet dispensing, transport, fusion, and particle extraction.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC3964134 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Full-range magnetic manipulation of droplets via surface energy traps enables complex bioassays.

Zhang Yi Y Wang Tza-Huei TH

Advanced materials (Deerfield Beach, Fla.) 20130326 21

Manipulating droplets on an open surface promises an easier, more flexible, and more scalable platform of liquid control, than does microchannel-based fluidics. In this report, a surface-energy-trap-enabled magnetic droplet handling platform is introduced that is capable of comprehensive droplet manipulations, including droplet dispensing, transport, fusion, and particle extraction. ...[more]

PMID: 23529938

Similar Datasets

Serial dilution via surface energy trap-assisted magnetic droplet manipulation.

Project description:This paper demonstrates a facile method of generating precise serial dilutions in the form of droplets on an open surface platform. The method relies on the use of surface energy traps (SETs), etched areas of high surface energy on a Teflon coated glass substrate, to assist in the magnetic manipulation of droplets to meter and dispense liquid of defined volumes for the preparation of serial dilutions. The volume of the dispensed liquid can be precisely controlled by the size of the SETs, facilitating generation of concentration profiles of high linearity. We have applied this approach to the generation of serial dilutions of antibiotics for anti-microbial susceptibility testing (AST).

| S-EPMC3963271 | biostudies-literature

Manipulation of magnetically labeled and unlabeled cells with mobile magnetic traps.

Project description:A platform of discrete microscopic magnetic elements patterned on a surface offers dynamic control over the motion of fluid-borne cells by reprogramming the magnetization within the magnetic bits. T-lymphocyte cells tethered to magnetic microspheres and untethered leukemia cells are remotely manipulated and guided along desired trajectories on a silicon surface by directed forces with average speeds up to 20 microm/s. In addition to navigating cells, the microspheres can be operated from a distance to push biological and inert entities and act as local probes in fluidic environments.

| S-EPMC2814200 | biostudies-literature

Remote Magnetic Nanoparticle Manipulation Enables the Dynamic Patterning of Cardiac Tissues.

Project description:The ability to manipulate cellular organization within soft materials has important potential in biomedicine and regenerative medicine; however, it often requires complex fabrication procedures. Here, a simple, cost-effective, and one-step approach that enables the control of cell orientation within 3D collagen hydrogels is developed to dynamically create various tailored microstructures of cardiac tissues. This is achieved by incorporating iron oxide nanoparticles into human cardiomyocytes and applying a short-term external magnetic field to orient the cells along the applied field to impart different shapes without any mechanical support. The patterned constructs are viable and functional, can be detected by T2 *-weighted magnetic resonance imaging, and induce no alteration to normal cardiac function after grafting onto rat hearts. This strategy paves the way to creating customized, macroscale, 3D tissue constructs with various cell-types for therapeutic and bioengineering applications, as well as providing powerful models for investigating tissue behavior.

| S-EPMC7015704 | biostudies-literature

Full voltage manipulation of the resistance of a magnetic tunnel junction.

Project description:One of the motivations for multiferroics research is to find an energy-efficient solution to spintronic applications, such as the solely electrical control of magnetic tunnel junctions. Here, we integrate spintronics and multiferroics by depositing MgO-based magnetic tunnel junctions on ferroelectric substrate. We fabricate two pairs of electrodes on the ferroelectric substrate to generate localized strain by applying voltage. This voltage-generated localized strain has the ability to modify the magnetic anisotropy of the free layer effectively. By sequentially applying voltages to these two pairs of electrodes, we successively and unidirectionally rotate the magnetization of the free layer in the magnetic tunnel junctions to complete reversible 180° magnetization switching. Thus, we accomplish a giant nonvolatile solely electrical switchable high/low resistance in magnetic tunnel junctions at room temperature without the aid of a magnetic field. Our results are important for exploring voltage control of magnetism and low-power spintronic devices.

| S-EPMC6910833 | biostudies-literature

Magnetic-Responsive Bendable Nozzles for Open Surface Droplet Manipulation.

Project description:The handling of droplets in a controlled manner is essential to numerous technological and scientific applications. In this work, we present a new open-surface platform for droplet manipulation based on an array of bendable nozzles that are dynamically controlled by a magnetic field. The actuation of these nozzles is possible thanks to the magnetically responsive elastomeric composite which forms the tips of the nozzles; this is fabricated with Fe3O4 microparticles embedded in a polydimethylsiloxane matrix. The transport, mixing, and splitting of droplets can be controlled by bringing together and separating the tips of these nozzles under the action of a magnet. Additionally, the characteristic configuration for droplet mixing in this platform harnesses the kinetic energy from the feeding streams; this provided a remarkable reduction of 80% in the mixing time between drops of liquids about eight times more viscous than water, i.e., 6.5 mPa/s, when compared against the mixing between sessile drops of the same fluids.

| S-EPMC6918237 | biostudies-literature

Microspinning: Local Surface Mixing via Rotation of Magnetic Microparticles for Efficient Small-Volume Bioassays.

Project description:The need for high-throughput screening has led to the miniaturization of the reaction volume of the chamber in bioassays. As the reactor gets smaller, surface tension dominates the gravitational or inertial force, and mixing efficiency decreases in small-scale reactions. Because passive mixing by simple diffusion in tens of microliter-scale volumes takes a long time, active mixing is needed. Here, we report an efficient micromixing method using magnetically rotating microparticles with patterned magnetization induced by magnetic nanoparticle chains. Because the microparticles have magnetization patterning due to fabrication with magnetic nanoparticle chains, the microparticles can rotate along the external rotating magnetic field, causing micromixing. We validated the reaction efficiency by comparing this micromixing method with other mixing methods such as simple diffusion and the use of a rocking shaker at various working volumes. This method has the potential to be widely utilized in suspension assay technology as an efficient mixing strategy.

| S-EPMC7074623 | biostudies-literature

Manipulation of surface charges of oil droplets and carbonate rocks to improve oil recovery.

Project description:This work investigates the effect of the surface charges of oil droplets and carbonate rocks in brine and in surfactant solutions on oil production. The influences of the cations in brine and the surfactant types on the zeta-potentials of both oil droplets and carbonate rock particles are studied. It is found that the addition of anionic and cationic surfactants in brine result in both negative or positive zeta-potentials of rock particles and oil droplets respectively, while the zwitterionic surfactant induces a positive charge on rock particles and a negative charge on oil droplets. Micromodels with a CaCO3 nanocrystal layer coated on the flow channels were used in the oil displacement tests. The results show that when the oil-water interfacial tension (IFT) was at 10-1 mN/m, the injection of an anionic surfactant (SDS-R1) solution achieved 21.0% incremental oil recovery, higher than the 12.6% increment by the injection of a zwitterionic surfactant (SB-A2) solution. When the IFT was lowered to 10-3 mM/m, the injection of anionic/non-ionic surfactant SMAN-l1 solution with higher absolute zeta potential value (ζoil + ζrock) of 34 mV has achieved higher incremental oil recovery (39.4%) than the application of an anionic/cationic surfactant SMAC-l1 solution with a lower absolute zeta-potential value of 22 mV (30.6%). This indicates that the same charge of rocks and oil droplets improves the transportation of charged oil/water emulsion in the porous media. This work reveals that the surface charge in surfactant flooding plays an important role in addition to the oil/water interfacial tension reduction and the rock wettability alteration.

| S-EPMC8282872 | biostudies-literature

Magnetic Beads inside Droplets for Agitation and Splitting Manipulation by Utilizing a Magnetically Actuated Platform.

Project description:We successfully developed a platform for the magnetic manipulation of droplets containing magnetic beads and examined the washing behaviors of the droplets, including droplet transportation, magnetic bead agitation inside droplets, and separation from parent droplets. Magnetic field gradients were produced with two layers of 6 × 1 planar coils fabricated by using printed circuit board technology. We performed theoretical analyses to understand the characteristics of the coils and successfully predicted the magnetic field and thermal temperature of a single coil. We then investigated experimentally the agitation and splitting kinetics of the magnetic beads inside droplets and experimentally observed the washing performance in different neck-shaped gaps. The performance of the washing process was evaluated by measuring both the particle loss ratio and the optical density. The findings of this work will be used to design a magnetic-actuated droplet platform, which will separate magnetic beads from their parent droplets and enhance washing performance. We hope that this study will provide digital microfluidics for application in point-of-care testing. The developed microchip will be of great benefit for genetic analysis and infectious disease detection in the future.

| S-EPMC10384566 | biostudies-literature

Optical Dielectrophoretic (DEP) Manipulation of Oil-Immersed Aqueous Droplets on a Plasmonic-Enhanced Photoconductive Surface.

Project description:We present a plasmonic-enhanced dielectrophoretic (DEP) phenomenon to improve optical DEP performance of a floating electrode optoelectronic tweezers (FEOET) device, where aqueous droplets can be effectively manipulated on a light-patterned photoconductive surface immersed in an oil medium. To offer device simplicity and cost-effectiveness, recent studies have utilized a polymer-based photoconductive material such as titanium oxide phthalocyanine (TiOPc). However, the TiOPc has much poorer photoconductivity than that of semiconductors like amorphous silicon (a-Si), significantly limiting optical DEP applications. The study herein focuses on the FEOET device for which optical DEP performance can be greatly enhanced by utilizing plasmonic nanoparticles as light scattering elements to improve light absorption of the low-quality TiOPc. Numerical simulation studies of both plasmonic light scattering and electric field enhancement were conducted to verify wide-angle scattering light rays and an approximately twofold increase in electric field gradient with the presence of nanoparticles. Similarly, a spectrophotometric study conducted on the absorption spectrum of the TiOPc has shown light absorption improvement (nearly twofold) of the TiOPc layer. Additionally, droplet dynamics study experimentally demonstrated a light-actuated droplet speed of 1.90 mm/s, a more than 11-fold improvement due to plasmonic light scattering. This plasmonic-enhanced FEOET technology can considerably improve optical DEP capability even with poor-quality photoconductive materials, thus providing low-cost, easy-fabrication solutions for various droplet-based microfluidic applications.

| S-EPMC8777958 | biostudies-literature

Formation and manipulation of ferrofluid droplets with magnetic fields in a microdevice: a numerical parametric study.

Project description:We present a numerical model that describes the microfluidic generation and manipulation of ferrofluid droplets under an external magnetic field. We developed a numerical Computational Fluid Dynamics (CFD) analysis for predicting and optimizing continuous flow generation and processing of ferrofluid droplets with and without the presence of a permanent magnet. More specifically, we explore the dynamics of oil-based ferrofluid droplets within an aqueous continuous phase under an external inhomogeneous magnetic field. The developed model determines the effect of the magnetic field on the droplet generation, which is carried out in a flow-focusing geometry, and its sorting in T-junction channels. Three-channel depths (25 μm, 30 μm, and 40 μm) were investigated to study droplet deformation under magnetic forces. Among the three, the 30 μm channel depth showed the most consistent droplet production for the studied range of flow rates. Ferrofluids with different loadings of magnetic nanoparticles were used to observe the behavior for different ratios of magnetic and hydrodynamic forces. Our results show that the effect of these factors on droplet size and generation rate can be tuned and optimized to produce consistent droplet generation and sorting. This approach involves fully coupled magnetic-fluid mechanics models and can predict critical details of the process including droplet size, shape, trajectory, dispensing rate, and the perturbation of the fluid co-flow for different flow rates. The model enables better understanding of the physical phenomena involved in continuous droplet processing and allows efficient parametric analysis and optimization.

| S-EPMC8256729 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data