Ontology highlight
ABSTRACT:
SUBMITTER: Kirsanov KI
PROVIDER: S-EPMC3964218 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Kirsanov Kirill I KI Kotova Elena E Makhov Petr P Golovine Konstantin K Lesovaya Ekaterina A EA Kolenko Vladimir M VM Yakubovskaya Marianna G MG Tulin Alexei V AV
Oncotarget 20140101 2
PARP-1 is a nuclear enzyme regulating transcription, chromatin restructuring, and DNA repair. PARP-1 is activated by interaction with NAD+, DNA, and core histones. Each route of PARP-1 activation leads to somewhat different outcomes. PARP-1 interactions with core histones control PARP-1 functions during transcriptional activation in euchromatin. DNA-dependent regulation of PARP-1 determines its localization in heterochromatin and PARP-1-dependent silencing. Here we address the biological signifi ...[more]