Ontology highlight
ABSTRACT:
SUBMITTER: Elokely K
PROVIDER: S-EPMC4720335 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Elokely Khaled K Velisetty Phanindra P Delemotte Lucie L Palovcak Eugene E Klein Michael L ML Rohacs Tibor T Carnevale Vincenzo V
Proceedings of the National Academy of Sciences of the United States of America 20151230 2
The transient receptor potential cation channel subfamily V member 1 (TRPV1) or vanilloid receptor 1 is a nonselective cation channel that is involved in the detection and transduction of nociceptive stimuli. Inflammation and nerve damage result in the up-regulation of TRPV1 transcription, and, therefore, modulators of TRPV1 channels are potentially useful in the treatment of inflammatory and neuropathic pain. Understanding the binding modes of known ligands would significantly contribute to the ...[more]