Ontology highlight
ABSTRACT:
SUBMITTER: Illes S
PROVIDER: S-EPMC3964285 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Illes Sebastian S Jakab Martin M Beyer Felix F Gelfert Renate R Couillard-Despres Sébastien S Schnitzler Alfons A Ritter Markus M Aigner Ludwig L
Stem cell reports 20140220 3
Neurons generated from pluripotent stem cells (PSCs) self-organize into functional neuronal assemblies in vitro, generating synchronous network activities. Intriguingly, PSC-derived neuronal assemblies develop spontaneous activities that are independent of external stimulation, suggesting the presence of thus far undetected intrinsically active neurons (IANs). Here, by using mouse embryonic stem cells, we provide evidence for the existence of IANs in PSC-neuronal networks based on extracellular ...[more]