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Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.

ABSTRACT: The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.

SUBMITTER: Wang X

PROVIDER: S-EPMC3964319 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.

Wang Xiachang X Elshahawi Sherif I SI Shaaban Khaled A KA Fang Lei L Ponomareva Larissa V LV Zhang Yinan Y Copley Gregory C GC Hower James C JC Zhan Chang-Guo CG Kharel Madan K MK Thorson Jon S JS

Organic letters 20131216 2

The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to displa ...[more]

PMID: 24341358

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