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Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2.

ABSTRACT: The structures of 12 new "enantiomeric"-like abyssomicin metabolites (abyssomicins M-X) from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the first reported naturally occurring linear spirotetronate. Metabolite structures were determined based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2 genome sequencing also revealed the corresponding putative biosynthetic gene cluster.

SUBMITTER: Wang X

PROVIDER: S-EPMC5558431 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2.

Wang Xiachang X Elshahawi Sherif I SI Cai Wenlong W Zhang Yinan Y Ponomareva Larissa V LV Chen Xiabin X Copley Gregory C GC Hower James C JC Zhan Chang-Guo CG Parkin Sean S Rohr Jürgen J Van Lanen Steven G SG Shaaban Khaled A KA Thorson Jon S JS

Journal of natural products 20170330 4

The structures of 12 new "enantiomeric"-like abyssomicin metabolites (abyssomicins M-X) from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the first reported naturally occurring linear spirotetronate. Metabolite structures were determined based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2 genome sequencing also revealed the corresponding ...[more]

PMID: 28358212

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