Ontology highlight
ABSTRACT:
SUBMITTER: Steiner T
PROVIDER: S-EPMC3965423 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Steiner Tanja T Francescut Lorenza L Byrne Simon S Hughes Timothy T Jayanthi Archana A Guschina Irina I Harwood John J Cianflone Katherine K Stover Cordula C Francis Sheila S
PloS one 20140325 3
Genetic, dietary and immune factors contribute to the pathogenesis of atherosclerosis in humans and mice. Complement activation is an integral part of the innate immune defence but also shapes cellular responses and influences directly triglyceride synthesis. Deficiency of Factor B of the alternative pathway (AP) of complement is beneficial in LDLR(-/-) mice fed a high fat diet. The serum glycoprotein properdin is a key positive regulator of the AP but has not been studied in experimental athero ...[more]