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ABSTRACT: Background
The serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space. A blood-brain relationship between platelet and synaptosomal 5-HT reuptake has been suggested, but it is unknown today, if platelet 5-HT uptake can predict neural activation of human brain networks that are known to be under serotonergic influence.Methods
A functional magnetic resonance study was performed in 48 healthy subjects and maximal 5-HT uptake velocity (Vmax) was assessed in blood platelets. We used a mixed-effects multilevel analysis technique (MEMA) to test for linear relationships between whole-brain, blood-oxygen-level dependent (BOLD) activity and platelet Vmax.Results
The present study demonstrates that increases in platelet Vmax significantly predict default-mode network (DMN) suppression in healthy subjects independent of genetic variation within SLC6A4. Furthermore, functional connectivity analyses indicate that platelet Vmax is related to global DMN activation and not intrinsic DMN connectivity.Conclusion
This study provides evidence that platelet Vmax predicts global DMN activation changes in healthy subjects. Given previous reports on platelet-synaptosomal Vmax coupling, results further suggest an important role of neuronal 5-HT reuptake in DMN regulation.
SUBMITTER: Scharinger C
PROVIDER: S-EPMC3965432 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Scharinger Christian C Rabl Ulrich U Kasess Christian H CH Meyer Bernhard M BM Hofmaier Tina T Diers Kersten K Bartova Lucie L Pail Gerald G Huf Wolfgang W Uzelac Zeljko Z Hartinger Beate B Kalcher Klaudius K Perkmann Thomas T Haslacher Helmuth H Meyer-Lindenberg Andreas A Kasper Siegfried S Freissmuth Michael M Windischberger Christian C Willeit Matthäus M Lanzenberger Rupert R Esterbauer Harald H Brocke Burkhard B Moser Ewald E Sitte Harald H HH Pezawas Lukas L
PloS one 20140325 3
<h4>Background</h4>The serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space. A blood-brain relationship between platelet and synaptosomal 5-HT reuptake has been suggested, but it is unknown today, if platelet 5-HT uptake can predict neural activation of human brain networks that are known to be under serotonergic influence.<h4>Methods</h4>A functional magnetic resonance study was performed i ...[more]