Ontology highlight
ABSTRACT:
SUBMITTER: Schott BH
PROVIDER: S-EPMC3966038 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Schott B H BH Assmann A A Schmierer P P Soch J J Erk S S Garbusow M M Mohnke S S Pöhland L L Romanczuk-Seiferth N N Barman A A Wüstenberg T T Haddad L L Grimm O O Witt S S Richter S S Klein M M Schütze H H Mühleisen T W TW Cichon S S Rietschel M M Noethen M M MM Tost H H Gundelfinger E D ED Düzel E E Heinz A A Meyer-Lindenberg A A Seidenbecher C I CI Walter H H
Translational psychiatry 20140318
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. Previous neuroimaging studies of depression-related endophenotypes have highlighted the role of the subgenual cingulate cortex (CG25) in negative mood and depressive psychopathology. Here, we a ...[more]