Ontology highlight
ABSTRACT:
SUBMITTER: Shafi S
PROVIDER: S-EPMC3966512 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Shafi Seema S Vantourout Pierre P Wallace Graham G Antoun Ayman A Vaughan Robert R Stanford Miles M Hayday Adrian A
Science translational medicine 20111130 113
DNA damage or other physicochemical stresses may increase the expression of major histocompatibility complex class I-related stress antigens, which then activate lymphocytes. This lymphoid stress surveillance (LSS) not only can limit tumor formation but may also promote immunopathology. MICA is a highly polymorphic human stress antigen implicated in tumor surveillance, inflammation, and transplant rejection. However, LSS has not been conclusively demonstrated in humans, and the functional role f ...[more]