Ontology highlight
ABSTRACT:
SUBMITTER: Stolberg-Stolberg JA
PROVIDER: S-EPMC3966619 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Stolberg-Stolberg Josef A JA Furman Bridgette D BD Garrigues N William NW Lee Jaewoo J Pisetsky David S DS Stearns Nancy A NA DeFrate Louis E LE Guilak Farshid F Olson Steven A SA
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20130425 8
Post-traumatic arthritis (PTA) frequently develops after intra-articular fracture of weight bearing joints. Loss of cartilage viability and post-injury inflammation have both been implicated as possible contributing factors to PTA progression. To further investigate chondrocyte response to impact and fracture, we developed a blunt impact model applying 70%, 80%, or 90% surface-to-surface compressive strain with or without induction of an articular fracture in a cartilage explant model. Following ...[more]