Ontology highlight
ABSTRACT:
SUBMITTER: Smits JP
PROVIDER: S-EPMC3967447 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20111004 21
The α-trisphosphonic acid esters provide a unique spatial arrangement of three phosphonate groups and may represent an attractive motif for inhibitors of enzymes that utilize di- or triphosphate substrates. To advance studies of this unique functionality, a general route to alkyl derivatives of the parent system (R = H) has been developed. A set of new α-alkyl-1,1,1-trisphosphonate esters has been prepared through phosphinylation and subsequent oxidation of tetraethyl alkylbisphosphonates, and t ...[more]