Ontology highlight
ABSTRACT:
SUBMITTER: Samanta SS
PROVIDER: S-EPMC7189931 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
European journal of organic chemistry 20190824 39
A general and efficient synthesis of α-haloglycine esters from commercially available feedstock chemicals, in a single step, is reported. The reactivity of these α-haloglycine esters with various nucleophiles was studied as surrogates of α-iminoesters upon activation with hydrogen-bond donor catalysts. DFT calculations on the α-haloglycine structures (X = F, Cl, Br) accompanied by an X-ray characterization of the α-bromoglycine ester support the existence of a "generalized" anomeric effect creat ...[more]