Ontology highlight
ABSTRACT:
SUBMITTER: Shah N
PROVIDER: S-EPMC3967590 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Shah Nilay N Jin Kideok K Cruz Leigh-Ann LA Park Sunju S Sadik Helen H Cho Soonweng S Goswami Chirayu Pankaj CP Nakshatri Harikrishna H Gupta Rajnish R Chang Howard Y HY Zhang Zhe Z Cimino-Mathews Ashley A Cope Leslie L Umbricht Christopher C Sukumar Saraswati S
Cancer research 20130705 17
Most breast cancers expressing the estrogen receptor α (ERα) are treated successfully with the receptor antagonist tamoxifen (TAM), but many of these tumors recur. Elevated expression of the homeodomain transcription factor HOXB13 correlates with TAM-resistance in ERα-positive (ER+) breast cancer, but little is known regarding the underlying mechanism. Our comprehensive evaluation of HOX gene expression using tiling microarrays, with validation, showed that distant metastases from TAM-resistant ...[more]