Ontology highlight
ABSTRACT:
SUBMITTER: Guo F
PROVIDER: S-EPMC3967977 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Guo Fen F Carter David E DE Leask Andrew A
Molecular biology of the cell 20140205 7
Scarring, which occurs in essentially all adult tissue, is characterized by the excessive production and remodeling of extracellular matrix by α-smooth muscle actin (SMA)-expressing myofibroblasts located within connective tissue. Excessive scarring can cause organ failure and death. Oral gingivae do not scar. Compared to dermal fibroblasts, gingival fibroblasts are less responsive to transforming growth factor β (TGFβ) due to the reduced expression, due to the reduced expression and activity of ...[more]