Ontology highlight
ABSTRACT:
SUBMITTER: Alic N
PROVIDER: S-EPMC3969275 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Alic Nazif N Tullet Jennifer M JM Niccoli Teresa T Broughton Susan S Hoddinott Matthew P MP Slack Cathy C Gems David D Partridge Linda L
Cell reports 20140206 4
Drosophila melanogaster and Caenorhabditis elegans each carry a single representative of the Forkhead box O (FoxO) family of transcription factors, dFOXO and DAF-16, respectively. Both are required for lifespan extension by reduced insulin/Igf signaling, and their activation in key tissues can extend lifespan. Aging of these tissues may limit lifespan. Alternatively, FoxOs may promote longevity cell nonautonomously by signaling to themselves (FoxO to FoxO) or other factors (FoxO to other) in dis ...[more]