Ontology highlight
ABSTRACT:
SUBMITTER: Yue S
PROVIDER: S-EPMC3969850 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Yue Shuhua S Li Junjie J Lee Seung-Young SY Lee Hyeon Jeong HJ Shao Tian T Song Bing B Cheng Liang L Masterson Timothy A TA Liu Xiaoqi X Ratliff Timothy L TL Cheng Ji-Xin JX
Cell metabolism 20140301 3
Altered lipid metabolism is increasingly recognized as a signature of cancer cells. Enabled by label-free Raman spectromicroscopy, we performed quantitative analysis of lipogenesis at single-cell level in human patient cancerous tissues. Our imaging data revealed an unexpected, aberrant accumulation of esterified cholesterol in lipid droplets of high-grade prostate cancer and metastases. Biochemical study showed that such cholesteryl ester accumulation was a consequence of loss of tumor suppress ...[more]