Ontology highlight
ABSTRACT:
SUBMITTER: He WA
PROVIDER: S-EPMC3970508 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
He Wei A WA Calore Federica F Londhe Priya P Canella Alessandro A Guttridge Denis C DC Croce Carlo M CM
Proceedings of the National Academy of Sciences of the United States of America 20140310 12
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression and, in cancers, are often packaged within secreted microvesicles. The cachexia syndrome is a debilitating state of cancer that predominantly results from the loss of skeletal muscle mass, which is in part associated with apoptosis. How tumors promote apoptosis in distally located skeletal muscles has not been explored. Using both tumor cell lines and patient samples, we show that tumor-derived microvesicles induce apopto ...[more]