Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.
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ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC6015555 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.
Wang Gang G Biswas Anup K AK Ma Wanchao W Kandpal Manoj M Coker Courtney C Grandgenett Paul M PM Hollingsworth Michael A MA Jain Rinku R Tanji Kurenai K Lόpez-Pintado Sara S Borczuk Alain A Hebert Doreen D Jenkitkasemwong Supak S Hojyo Shintaro S Davuluri Ramana V RV Knutson Mitchell D MD Fukada Toshiyuki T Acharyya Swarnali S
Nature medicine 20180606 6
Patients with metastatic cancer experience a severe loss of skeletal muscle mass and function known as cachexia. Cachexia is associated with poor prognosis and accelerated death in patients with cancer, yet its underlying mechanisms remain poorly understood. Here, we identify the metal-ion transporter ZRT- and IRT-like protein 14 (ZIP14) as a critical mediator of cancer-induced cachexia. ZIP14 is upregulated in cachectic muscles of mice and in patients with metastatic cancer and can be induced b ...[more]
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