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Poly(ethylene imine)s as antimicrobial agents with selective activity.

ABSTRACT: We report the structure-activity relationship in the antimicrobial activity of linear and branched poly(ethylene imine)s (L- and B-PEIs) with a range of molecular weights (MWs) (500-12,000). Both L- and B-PEIs displayed enhanced activity against Staphylococcus aureus over Escherichia coli. Both B- and L-PEIs did not cause any significant permeabilization of E. coli cytoplasmic membrane. L-PEIs induced depolarization of S. aureus membrane although B-PEIs did not. The low MW B-PEIs caused little or no hemolysis while L-PEIs are hemolytic. The low MW B-PEIs are less cytotoxic to human HEp-2 cells than other PEIs. However, they induced significant cell viability reduction after 24 h incubation. The results presented here highlight the interplay between polymer size and structure on activity.

SUBMITTER: Gibney KA

PROVIDER: S-EPMC3970578 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Poly(ethylene imine)s as antimicrobial agents with selective activity.

Gibney Katherine A KA Sovadinova Iva I Lopez Analette I AI Urban Michael M Ridgway Zachary Z Caputo Gregory A GA Kuroda Kenichi K

Macromolecular bioscience 20120803 9

We report the structure-activity relationship in the antimicrobial activity of linear and branched poly(ethylene imine)s (L- and B-PEIs) with a range of molecular weights (MWs) (500-12,000). Both L- and B-PEIs displayed enhanced activity against Staphylococcus aureus over Escherichia coli. Both B- and L-PEIs did not cause any significant permeabilization of E. coli cytoplasmic membrane. L-PEIs induced depolarization of S. aureus membrane although B-PEIs did not. The low MW B-PEIs caused little o ...[more]

PMID: 22865776

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