Targeting deubiquitinating enzymes in cancer stem cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Lei H
PROVIDER: S-EPMC5670729 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Targeting deubiquitinating enzymes in cancer stem cells.
Lei Hu H Shan Huizhuang H Wu Yingli Y
Cancer cell international 20171103
Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential for CSC maintenance and differentiation, even leading to execute various stem cell fate choices. Deubiquitinating enzymes (DUBs), specifically disassembling ubiquitin chains, are important to maintain the balance between ubiquitination and deubiquitination. In this review, we have focused ...[more]
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