Protein N-acylation overrides differing targeting signals.
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ABSTRACT:
SUBMITTER: Stael S
PROVIDER: S-EPMC3971372 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Protein N-acylation overrides differing targeting signals.
Stael Simon S Bayer Roman G RG Mehlmer Norbert N Teige Markus M
FEBS letters 20110108 3
In a bioinformatics based screen for chloroplast-localized protein kinases we noticed that available protein targeting predictors falsely predicted chloroplast localization. This seems to be due to interference with N-terminal protein acylation, which is of particular importance for protein kinases. Their N-myristoylation was found to be highly overrepresented in the proteome, whereas myristoylation motifs are almost absent in known chloroplast proteins. However, only abolishing their myristoyla ...[more]
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