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Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy.

ABSTRACT: Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.

SUBMITTER: Coughlin AJ 

PROVIDER: S-EPMC3972071 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy.

Coughlin Andrew J AJ   Ananta Jeyarama S JS   Deng Nanfu N   Larina Irina V IV   Decuzzi Paolo P   West Jennifer L JL  

Small (Weinheim an der Bergstrasse, Germany) 20130923 3

Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultima  ...[more]

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