Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC3972824 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Liu Suyu S Yin Guosheng G Yuan Ying Y
The annals of applied statistics 20131201 4
A major practical impediment when implementing adaptive dose-finding designs is that the toxicity outcome used by the decision rules may not be observed shortly after the initiation of the treatment. To address this issue, we propose the data augmentation continual re-assessment method (DA-CRM) for dose finding. By naturally treating the unobserved toxicities as missing data, we show that such missing data are nonignorable in the sense that the missingness depends on the unobserved outcomes. The ...[more]