Ontology highlight
ABSTRACT:
SUBMITTER: Lapkouski M
PROVIDER: S-EPMC3973182 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Lapkouski Mikalai M Tian Lan L Miller Jennifer T JT Le Grice Stuart F J SFJ Yang Wei W
Nature structural & molecular biology 20130113 2
Hundreds of structures of type 1 human immunodeficiency virus (HIV-1) reverse transcriptase (RT) have been determined, but only one contains an RNA/DNA hybrid. Here we report three structures of HIV-1 RT complexed with a non-nucleotide RT inhibitor (NNRTI) and an RNA/DNA hybrid. In the presence of an NNRTI, the RNA/DNA structure differs from all prior nucleic acid-RT structures including the RNA/DNA hybrid. The enzyme structure also differs from all previous RT-DNA complexes. Thus, the hybrid ha ...[more]