Ontology highlight
ABSTRACT:
SUBMITTER: Keane SC
PROVIDER: S-EPMC4492308 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20150501 6237
The 5' leader of the HIV-1 genome contains conserved elements that direct selective packaging of the unspliced, dimeric viral RNA into assembling particles. By using a (2)H-edited nuclear magnetic resonance (NMR) approach, we determined the structure of a 155-nucleotide region of the leader that is independently capable of directing packaging (core encapsidation signal; Ψ(CES)). The RNA adopts an unexpected tandem three-way junction structure, in which residues of the major splice donor and tran ...[more]