Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC3973209 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Cell death & disease 20140327
p53 is an important inducer of organismal aging. However, its roles in the aging of skin remain unclear. Here we show that mice with chronic activation of p53 develop an aging phenotype in the skin associated with a reduction of subcutaneous fat and loss of sebaceous gland (SG). The reduction in the fat layer may result from the decrease of mammalian TOR complex 1 (mTORC1) activity accompanied by elevated expression of energy expenditure genes, and possibly as compensatory effects, leading to th ...[more]