Ontology highlight
ABSTRACT:
SUBMITTER: Dahlhoff M
PROVIDER: S-EPMC4135600 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Dahlhoff Maik M Frances Daniela D Kloepper Jennifer E JE Paus Ralf R Schäfer Matthias M Niemann Catherin C Schneider Marlon R MR
Molecular and cellular biology 20140602 16
The epidermal growth factor receptor (EGFR) system is a key regulator of epithelial development and homeostasis. Its functions in the sebaceous gland (SG), however, remain poorly characterized. In this study, using a transgenic mouse line with tissue-specific and inducible expression of the EGFR ligand epigen, we showed that increased activation of the EGFR in skin keratinocytes results in enlarged SGs and increased sebum production. The phenotype can be reverted by interrupting transgene expres ...[more]