Ontology highlight
ABSTRACT:
SUBMITTER: Baschuk N
PROVIDER: S-EPMC3973215 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Baschuk N N Wang N N Watt S V SV Halse H H House C C Bird P I PI Strugnell R R Trapani J A JA Smyth M J MJ Andrews D M DM
Cell death & disease 20140313
Granzymes are generally recognized for their capacity to induce various pathways of perforin-dependent target cell death. Within this serine protease family, Granzyme M (GrzM) is unique owing to its preferential expression in innate effectors such as natural killer (NK) cells. During Listeria monocytogenes infection, we observed markedly reduced secretion of macrophage inflammatory protein-1 alpha (MIP-1α) in livers of GrzM-deficient mice, which resulted in significantly impaired NK cell recruit ...[more]