Ontology highlight
ABSTRACT:
SUBMITTER: Fitzgerald ME
PROVIDER: S-EPMC3973318 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Nucleic acids research 20140115 6
Dicer is a specialized nuclease that produces RNA molecules of specific lengths for use in gene silencing pathways. Dicer relies on the correct measurement of RNA target duplexes to generate products of specific lengths. It is thought that Dicer uses its multidomain architecture to calibrate RNA product length. However, this measurement model is derived from structural information from a protozoan Dicer, and does not account for the helicase domain present in higher organisms. The Caenorhabditis ...[more]