Unknown

Dataset Information

0

CD8? dendritic cells drive establishment of HSV-1 latency.

ABSTRACT: It is generally accepted that CD8 T cells play the key role to maintain HSV-1 latency in trigeminal ganglia of ocularly infected mice. Yet, comparably little is known about the role of innate immunity in establishment of viral latency. In the current study, we investigated whether CD8? DCs impact HSV-1 latency by examining latency in the trigeminal ganglia (TG) of wild-type (WT) C57BL/6 versus CD8?-/- (lack functional CD8 T cells and CD8?+ DCs), CD8?-/- (have functional CD8?+ T cells and CD8?+ DCs), and ?2m-/- (lack functional CD8 T cells but have CD8?+ DCs) mice as well as BXH2 (have functional CD8 T cells but lack CD8?+ DCs) versus WT C3H (have functional CD8? T cells and CD8?+ DCs) mice. We also determined whether the phenotype of CD8?-/- and BXH2 mice could be restored to that of WT mice by adoptive transfer of WT CD8+ T cells or bone marrow (BM) derived CD8?+ DCs. Our results clearly demonstrate that CD8? DCs, rather than CD8 T cells, are responsible for enhanced viral latency and recurrences.

SUBMITTER: Mott KR 

PROVIDER: S-EPMC3973679 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

It is generally accepted that CD8 T cells play the key role to maintain HSV-1 latency in trigeminal ganglia of ocularly infected mice. Yet, comparably little is known about the role of innate immunity in establishment of viral latency. In the current study, we investigated whether CD8α DCs impact HSV-1 latency by examining latency in the trigeminal ganglia (TG) of wild-type (WT) C57BL/6 versus CD8α-/- (lack functional CD8 T cells and CD8α+ DCs), CD8β-/- (have functional CD8α+ T cells and CD8α+ D  ...[more]

Similar Datasets

Unknown CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2.
| S-EPMC5105190 | biostudies-literature
Unknown Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection.
| S-EPMC3423191 | biostudies-literature
Unknown Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency.
| S-EPMC2680315 | biostudies-literature
Unknown Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1.
| S-EPMC6557749 | biostudies-literature
Unknown Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-?.
| S-EPMC3639491 | biostudies-literature
Unknown Langerin<sup>+</sup> CD8?<sup>+</sup> Dendritic Cells Drive Early CD8<sup>+</sup> T Cell Activation and IL-12 Production During Systemic Bacterial Infection.
| S-EPMC5949331 | biostudies-literature
Unknown Herpes simplex virus type 1 (HSV-1)-induced apoptosis in human dendritic cells as a result of downregulation of cellular FLICE-inhibitory protein and reduced expression of HSV-1 antiapoptotic latency-associated transcript sequences.
| S-EPMC2798353 | biostudies-literature
Unknown Cross-dressed CD8?+/CD103+ dendritic cells prime CD8+ T cells following vaccination.
| S-EPMC3411977 | biostudies-literature
Unknown HSV-2 Cellular Programming Enables Productive HIV Infection in Dendritic Cells.
| S-EPMC6909011 | biostudies-literature
Unknown HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal.
| S-EPMC10232005 | biostudies-literature