Ontology highlight
ABSTRACT:
SUBMITTER: Mott KR
PROVIDER: S-EPMC3973679 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mott Kevin R KR Allen Sariah J SJ Zandian Mandana M Konda Bindu B Sharifi Behrooz G BG Jones Clinton C Wechsler Steven L SL Town Terrence T Ghiasi Homayon H
PloS one 20140402 4
It is generally accepted that CD8 T cells play the key role to maintain HSV-1 latency in trigeminal ganglia of ocularly infected mice. Yet, comparably little is known about the role of innate immunity in establishment of viral latency. In the current study, we investigated whether CD8α DCs impact HSV-1 latency by examining latency in the trigeminal ganglia (TG) of wild-type (WT) C57BL/6 versus CD8α-/- (lack functional CD8 T cells and CD8α+ DCs), CD8β-/- (have functional CD8α+ T cells and CD8α+ D ...[more]