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CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2.

ABSTRACT: Tissue-resident memory CD8+ T (CD8 TRM) cells are an essential component of protective immune responses at barrier tissues, including the female genital tract. However, the mechanisms that lead to the initiation of CD8 TRM-mediated protective immunity after viral infection are unclear. Here we report that CD8 TRM cells established by 'prime and pull' method confer protection against genital HSV-2 infection, and that IFN-? produced by CD8 TRM cells is required for this protection. Furthermore, we find that CD8 TRM-cell restimulation depends on a population of CD301b+ antigen-presenting cells (APC) in the lamina propria. Elimination of MHC class I on CD301b+ dendritic cells abrogates protective immunity, suggesting the requirement for cognate antigen presentation to CD8 TRM cells by CD301b+ dendritic cells. These results define the requirements for CD8 TRM cells in protection against genital HSV-2 infection and identify the population of APC that are responsible for activating these cells.

SUBMITTER: Shin H 

PROVIDER: S-EPMC5105190 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2.

Shin Haina H   Kumamoto Yosuke Y   Gopinath Smita S   Iwasaki Akiko A  

Nature communications 20161109

Tissue-resident memory CD8+ T (CD8 T<sub>RM</sub>) cells are an essential component of protective immune responses at barrier tissues, including the female genital tract. However, the mechanisms that lead to the initiation of CD8 T<sub>RM</sub>-mediated protective immunity after viral infection are unclear. Here we report that CD8 T<sub>RM</sub> cells established by 'prime and pull' method confer protection against genital HSV-2 infection, and that IFN-γ produced by CD8 T<sub>RM</sub> cells is r  ...[more]

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