Ontology highlight
ABSTRACT:
SUBMITTER: Rajeswari M
PROVIDER: S-EPMC3974243 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Rajeswari Murugesan M Santhi Natchimuthu N Bhuvaneswari Vembu V
Bioinformation 20140319 3
Janus kinase 3 (JAK3) is a non-receptor tyrosine kinases family of protein which is comprised of JAK1, JAK2, JAK3 and TYK2. It plays an important role in immune function and lymphoid development and it only resides in the hematopoietic system. Therefore, selective targeting JAK3 is a rational approach in developing new therapeutic molecule. In this study, about 116 JAK3 inhibitors were collected from the literature and were used to build four-point pharmacophore model using Phase (Schrodinger mo ...[more]