Ontology highlight
ABSTRACT:
SUBMITTER: Ranasinghe S
PROVIDER: S-EPMC3974408 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Ranasinghe Srinika S Cutler Sam S Davis Isaiah I Lu Richard R Soghoian Damien Z DZ Qi Ying Y Sidney John J Kranias Gregory G Flanders Michael D MD Lindqvist Madelene M Kuhl Bjorn B Alter Galit G Deeks Steven G SG Walker Bruce D BD Gao Xiaojiang X Sette Alessandro A Carrington Mary M Streeck Hendrik H
Nature medicine 20130623 7
The contribution of HLA class II-restricted CD4(+) T cell responses to HIV immune control is poorly defined. Here, we delineated previously uncharacterized peptide-DRB1 restrictions in functional assays and analyzed the host genetic effects of HLA-DRB1 alleles on HIV viremia in a large cohort of HIV controllers and progressors. We found distinct stratifications in the effect of HLA-DRB1 alleles on HIV viremia, with HLA-DRB1*15:02 significantly associated with low viremia and HLA-DRB1*03:01 signi ...[more]