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Iron oxide nanoparticle encapsulated diatoms for magnetic delivery of small molecules to tumors.

ABSTRACT: Small molecules can be co-loaded with iron oxide nanoparticles onto diatoms. With an external magnetic field, the diatoms, after systemic administration, can be attracted to tumors. This study suggests a great potential of diatoms as a novel and powerful therapeutic vehicle.

SUBMITTER: Todd T 

PROVIDER: S-EPMC3974590 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Iron oxide nanoparticle encapsulated diatoms for magnetic delivery of small molecules to tumors.

Todd Trever T   Zhen Zipeng Z   Tang Wei W   Chen Hongmin H   Wang Geoffrey G   Chuang Yen-Jun YJ   Deaton Kayley K   Pan Zhengwei Z   Xie Jin J  

Nanoscale 20140103 4

Small molecules can be co-loaded with iron oxide nanoparticles onto diatoms. With an external magnetic field, the diatoms, after systemic administration, can be attracted to tumors. This study suggests a great potential of diatoms as a novel and powerful therapeutic vehicle. ...[more]

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