Ontology highlight
ABSTRACT:
SUBMITTER: Prokopenko I
PROVIDER: S-EPMC3974640 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Prokopenko Inga I Poon Wenny W Mägi Reedik R Prasad B Rashmi R Salehi S Albert SA Almgren Peter P Osmark Peter P Bouatia-Naji Nabila N Wierup Nils N Fall Tove T Stančáková Alena A Barker Adam A Lagou Vasiliki V Osmond Clive C Xie Weijia W Lahti Jari J Jackson Anne U AU Cheng Yu-Ching YC Liu Jie J O'Connell Jeffrey R JR Blomstedt Paul A PA Fadista Joao J Fadista Joao J Alkayyali Sami S Dayeh Tasnim T Ahlqvist Emma E Taneera Jalal J Lecoeur Cecile C Kumar Ashish A Hansson Ola O Hansson Karin K Voight Benjamin F BF Kang Hyun Min HM Levy-Marchal Claire C Vatin Vincent V Palotie Aarno A Syvänen Ann-Christine AC Mari Andrea A Weedon Michael N MN Loos Ruth J F RJ Ong Ken K KK Nilsson Peter P Isomaa Bo B Tuomi Tiinamaija T Wareham Nicholas J NJ Stumvoll Michael M Widen Elisabeth E Lakka Timo A TA Langenberg Claudia C Tönjes Anke A Rauramaa Rainer R Kuusisto Johanna J Frayling Timothy M TM Froguel Philippe P Walker Mark M Eriksson Johan G JG Ling Charlotte C Kovacs Peter P Ingelsson Erik E McCarthy Mark I MI Shuldiner Alan R AR Silver Kristi D KD Laakso Markku M Groop Leif L Lyssenko Valeriya V
PLoS genetics 20140403 4
Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion in different tissues. GRB10 knock-down in human pancreatic islets showed reduced insulin and glucag ...[more]