Ontology highlight
ABSTRACT:
SUBMITTER: Deng S
PROVIDER: S-EPMC3974793 | biostudies-literature | 2014 Jan-Feb
REPOSITORIES: biostudies-literature
Cell adhesion & migration 20130101 1
Recent discoveries have unveiled the roles of a complicated network of E3 ubiquitin ligases in regulating cell migration machineries. The E3 ubiquitin ligases Smurf1 and Cul/BACURD ubiquitinate RhoA to regulate stress fiber formation and cell polarity, and ASB2α ubiquitinates filamins to modulate cytoskeletal stiffness, thus regulating cell spreading and cell migration. HACE1, XIAP, and Skp1-Cul1-F-box bind to Rac1 and cause its ubiquitination and degradation, thus suppressing lamellipodium prot ...[more]