Ontology highlight
ABSTRACT:
SUBMITTER: Boyer NP
PROVIDER: S-EPMC7039193 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Boyer Nicholas P NP McCormick Laura E LE Menon Shalini S Urbina Fabio L FL Gupton Stephanie L SL
The Journal of cell biology 20200101 1
Appropriate axon guidance is necessary to form accurate neuronal connections. Axon guidance cues that stimulate cytoskeletal reorganization within the growth cone direct axon navigation. Filopodia at the growth cone periphery have long been considered sensors for axon guidance cues, yet how they respond to extracellular cues remains ill defined. Our previous work found that the filopodial actin polymerase VASP and consequently filopodial stability are negatively regulated via nondegradative TRIM ...[more]