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Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.

ABSTRACT: The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.

SUBMITTER: Tanomsing N 

PROVIDER: S-EPMC3974843 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.

Tanomsing Naowarat N   Mayxay Mayfong M   Newton Paul N PN   Nosten Francois F   Dolecek Christiane C   Hien Tran Tinh TT   White Nicholas J NJ   Day Nicholas P J NP   Dondorp Arjen M AM   Imwong Mallika M  

PloS one 20140403 4

The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance. ...[more]

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