Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XH
PROVIDER: S-EPMC3974915 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.
Zhang Xiang H-F XH Jin Xin X Malladi Srinivas S Zou Yilong Y Wen Yong H YH Brogi Edi E Smid Marcel M Foekens John A JA Massagué Joan J
Cell 20130801 5
How organ-specific metastatic traits arise in primary tumors remains unknown. Here, we show a role of the breast tumor stroma in selecting cancer cells that are primed for metastasis in bone. Cancer-associated fibroblasts (CAFs) in triple-negative (TN) breast tumors skew heterogeneous cancer cell populations toward a predominance of clones that thrive on the CAF-derived factors CXCL12 and IGF1. Limiting concentrations of these factors select for cancer cells with high Src activity, a known clini ...[more]
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