Ontology highlight
ABSTRACT:
SUBMITTER: Lee HK
PROVIDER: S-EPMC3975259 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Lee Hee Kyu HK Kim Hong Woo HW Lee In Yong IY Lee Jungmi J Lee Jaekyoo J Jung Dong Sik DS Lee Sang Yeop SY Park Sung Ho SH Hwang Haejun H Choi Jang-Sik JS Kim Jung-Ho JH Kim Se Won SW Kim Jung Keun JK Cools Jan J Koh Jong Sung JS Song Ho-Juhn HJ
Blood 20140214 14
Aberrant activations of Fms-like tyrosine receptor kinase (FLT) 3 are implicated in the pathogenesis of 20% to 30% of patients with acute myeloid leukemia (AML). G-749 is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays. G-749 retained its inhibitory potency in various drug-resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection. F ...[more]