Ontology highlight
ABSTRACT:
SUBMITTER: Green AS
PROVIDER: S-EPMC4643770 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Green Alexa S AS Maciel Thiago T TT Hospital Marie-Anne MA Yin Chae C Mazed Fetta F Townsend Elizabeth C EC Pilorge Sylvain S Lambert Mireille M Paubelle Etienne E Jacquel Arnaud A Zylbersztejn Florence F Decroocq Justine J Poulain Laury L Sujobert Pierre P Jacque Nathalie N Adam Kevin K So Jason C C JC Kosmider Olivier O Auberger Patrick P Hermine Olivier O Weinstock David M DM Lacombe Catherine C Mayeux Patrick P Vanasse Gary J GJ Leung Anskar Y AY Moura Ivan C IC Bouscary Didier D Tamburini Jerome J
Science advances 20150918 8
Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is frequently detected in acute myeloid leukemia (AML) patients and is associated with a dismal long-term prognosis. FLT3 tyrosine kinase inhibitors provide short-term disease control, but relapse invariably occurs within months. Pim protein kinases are oncogenic FLT3-ITD targets expressed in AML cells. We show that increased Pim kinase expression is found in relapse samples from AML patients treated with FLT3 inhibitors. Ectopic ...[more]