Ontology highlight
ABSTRACT:
SUBMITTER: Bendix I
PROVIDER: S-EPMC3975367 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Bendix Ivo I Serdar Meray M Herz Josephine J von Haefen Clarissa C Nasser Fatme F Rohrer Benjamin B Endesfelder Stefanie S Felderhoff-Mueser Ursula U Spies Claudia D CD Sifringer Marco M
International journal of molecular sciences 20140303 3
Exposure to N-methyl-d-aspartate (NMDA) receptor antagonists has been demonstrated to induce neurodegeneration in newborn rats. However, in clinical practice the use of NMDA receptor antagonists as anesthetics and sedatives cannot always be avoided. The present study investigated the effect of the indirect cholinergic agonist physostigmine on neurotrophin expression and the extracellular matrix during NMDA receptor antagonist induced injury to the immature rat brain. The aim was to investigate m ...[more]