Structural and molecular modeling features of P2X receptors.
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ABSTRACT:
SUBMITTER: Alves LA
PROVIDER: S-EPMC3975412 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Structural and molecular modeling features of P2X receptors.
Alves Luiz Anastacio LA da Silva João Herminio Martins JH Ferreira Dinarte Neto Moreira DN Fidalgo-Neto Antonio Augusto AA Teixeira Pedro Celso Nogueira PC de Souza Cristina Alves Magalhães CA Caffarena Ernesto Raúl ER de Freitas Mônica Santos MS
International journal of molecular sciences 20140314 3
Currently, adenosine 5'-triphosphate (ATP) is recognized as the extracellular messenger that acts through P2 receptors. P2 receptors are divided into two subtypes: P2Y metabotropic receptors and P2X ionotropic receptors, both of which are found in virtually all mammalian cell types studied. Due to the difficulty in studying membrane protein structures by X-ray crystallography or NMR techniques, there is little information about these structures available in the literature. Two structures of the ...[more]
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