Ontology highlight
ABSTRACT:
SUBMITTER: Kasuya G
PROVIDER: S-EPMC5362899 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Kasuya Go G Fujiwara Yuichiro Y Tsukamoto Hisao H Morinaga Satoshi S Ryu Satoshi S Touhara Kazushige K Ishitani Ryuichiro R Furutani Yuji Y Hattori Motoyuki M Nureki Osamu O
Scientific reports 20170323
P2X receptors are trimeric ATP-gated cation channels involved in diverse physiological processes, ranging from muscle contraction to nociception. Despite the recent structure determination of the ATP-bound P2X receptors, the molecular mechanism of the nucleotide base specificity has remained elusive. Here, we present the crystal structure of zebrafish P2X4 in complex with a weak affinity agonist, CTP, together with structure-based electrophysiological and spectroscopic analyses. The CTP-bound st ...[more]