Ontology highlight
ABSTRACT:
SUBMITTER: Cui J
PROVIDER: S-EPMC3975496 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Cui Jun J Song Yanxia Y Li Yinyin Y Zhu Qingyuan Q Tan Peng P Qin Yunfei Y Wang Helen Y HY Wang Rong-Fu RF
Cell research 20131224 4
Lysine 63 (K63)-linked ubiquitination of RIG-I plays a critical role in the activation of type I interferon pathway, yet the molecular mechanism responsible for its deubiquitination is still poorly understood. Here we report that the deubiquitination enzyme ubiquitin-specific protease 3 (USP3) negatively regulates the activation of type I interferon signaling by targeting RIG-I. Knockdown of USP3 specifically enhanced K63-linked ubiquitination of RIG-I, upregulated the phosphorylation of IRF3 an ...[more]